ミスマッチ修復能を有する子宮内膜がん患者を対象とした、サシツズマブ・ティルモテカン（MK-2870）とペムブロリズマブ（MK-3475）の併用療法とペムブロリズマブ単独療法を比較する試験（MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29）

基本情報

NCT ID: NCT06952504
ステータス: 募集中
試験のフェーズ: 第3相
試験タイプ: 介入
目標被験者数: 1,123
治験依頼者名: Merck Sharp & Dohme LLC

概要

Researchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advanced or recurrent. * EC is a type of cancer that starts in the tissues inside the uterus (womb) * pMMR indicates that certain normal proteins are present in the cancer cells * Advanced means the cancer has spread locally or to other parts of the body (metastatic) and cannot be removed with surgery * Recurrent means the cancer came back after surgery Sacituzumab tirumotecan (also known as sac-TMT) and pembrolizumab are the study medicines. Sac-TMT is an antibody drug conjugate (ADC). An ADC attaches to specific targets on cancer cells and delivers treatment to destroy those cells. The goal of this study is to learn if people who receive sac-TMT with pembrolizumab live longer and without the cancer getting worse compared to people who receive pembrolizumab alone.

対象疾患

子宮内膜がん

介入

Pembrolizumab(BIOLOGICAL)

Carboplatin(DRUG)

Paclitaxel(DRUG)

Docetaxel(DRUG)

Sacituzumab Tirumotecan(BIOLOGICAL)

依頼者（Sponsor）

MSD株式会社(INDUSTRY)

実施施設 (20)

群馬県立がんセンター

Ōta, Gunma, Japan(RECRUITING)

独立行政法人国立病院機構　九州がんセンター

Fukuoka, Japan(RECRUITING)

公益財団法人がん研究会　有明病院

Koto, Tokyo, Japan(RECRUITING)

独立行政法人国立病院機構四国がんセンター

Matsuyama, Ehime, Japan(RECRUITING)

久留米大学病院

Kurume, Fukuoka, Japan(RECRUITING)

新潟県立がんセンター新潟病院

Niigata, Japan(RECRUITING)

愛媛県立今治病院

Tōon, Ehime, Japan(RECRUITING)

National Cancer Center Hospital ( Site 2211)

Chūō, Tokyo, Japan(RECRUITING)

Cancer Institute Hospital of JFCR ( Site 2208)

Koto, Tokyo, Japan(RECRUITING)

兵庫県立がんセンター

Akashi, Hyōgo, Japan(RECRUITING)

Saitama Medical University International Medical Center ( Site 2201)

Hidaka, Saitama, Japan(RECRUITING)

独立行政法人国立病院機構北海道がんセンター

Sapporo, Hokkaido, Japan(RECRUITING)

慶應義塾大学病院

Shinjuku, Tokyo, Japan(RECRUITING)

Keio University Hospital ( Site 2209)

Shinjuku, Tokyo, Japan(RECRUITING)

国立研究開発法人国立がん研究センター中央病院

Chūō, Tokyo, Japan(RECRUITING)

岩手医科大学附属病院

Shiwa-gun, Iwate, Japan(RECRUITING)

Kurume University Hospital ( Site 2204)

Kurume, Fukuoka, Japan(RECRUITING)

埼玉医科大学国際医療センター

Hidaka, Saitama, Japan(RECRUITING)

愛媛大学医学部附属病院

Tōon, Ehime, Japan(RECRUITING)

岡山大学病院

Okayama, Japan(RECRUITING)