急性視神経炎ネットワーク：初めて急性視神経炎を発症した被験者を対象とした国際研究

基本情報

NCT ID: NCT05605951
ステータス: 不明
試験のフェーズ: -
試験タイプ: 観察
目標被験者数: 200
治験依頼者名: Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecul

概要

The goal of this observational study is to longitudinally investigating subjects with inaugural acute optic neuritis (ON). The main questions it aims to answer are: * Does the time to corticosteroid treatment affect the visual outcome at 6 months in subjects with acute multiple sclerosis (MS)-, aquaporin 4-IgG positive (AQP4-IgG+) and myelin-oligodendrocyte-glycoprotein-IgG positive (MOG-IgG+) ON? * How differ clinical, structural, and laboratory biomarkers in subjects with acute ON, including clinical isolated syndrome (CIS), MS-ON, AQP4-IgG+ON, MOG-IgG+ON and seronegative non-MS-ON? Participants will undergo * clinical examination, including clinical history, neurovisual and neurological tests * serum and cerebrospinal fluid examination * optical coherence tomography (OCT) * magnetic resonance imaging (MRI) * assessment of depression, pain, quality of life through validated questionnaires Researchers will compare subjects with MS-ON, AQP4-IgG+ON, MOG-IgG+ON and other ON (CIS, seronegative non-MS-ON) to detect diagnostic and predictive markers for the disease course.

対象疾患

Demyelinating DiseasesMultiple SclerosisNeuromyelitis Optica Spectrum Disorder AttackMyelin Oligodendrocyte Glycoprotein Antibody-associated DiseaseOptic Neuritis

介入

non-interventional study(OTHER)

依頼者（Sponsor）

Experimental And Clinical Research Center, A Cooperation Between The Max Delbrück Center For Molecul(OTHER)

実施施設 (1)

福島内科医院

Fukushima, Japan(NOT_YET_RECRUITING)