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うつ伏せ姿勢と自発呼吸

基本情報

NCT ID
NCT03768154
ステータス
不明
試験のフェーズ
第1相
試験タイプ
介入
目標被験者数
12
治験依頼者名
Osaka University

概要

Spontaneous breathing during mechanical ventilation has been recommended in patients with ARDS and is currently used. in part because oxygenation is better and there is a lower risk of diaphragm dysfunction due to disuse. The other approach to minimizing lung injury from spontaneous effort is the use of neuromuscular blockade; an early and short term (48 hours) of neuromuscular blockade in patients with severe ARDS has been shown to decrease inflammation and to improve survival. The investigators propose a pilot study to test the feasibility and the physiological effects of allowing spontaneous breathing in the prone position in patients with ARDS.

対象疾患

Critical IllnessARDS

介入

Supine + spontaneous effort(PROCEDURE)
Supine + paralysis(PROCEDURE)
Prone + paralysis(PROCEDURE)
Prone + spontaneous breathing(PROCEDURE)

依頼者(Sponsor)

実施施設 (1)

大阪大学医学部附属病院

Suita, Osaka, Japan