L-カルニチンは肝切除患者のアンモニア代謝を改善する

基本情報

NCT ID

NCT03021876

ステータス

不明

試験のフェーズ

第2/第3相

試験タイプ

介入

目標被験者数

80

治験依頼者名

Kochi University

概要

L-carnitine is synthesized from lysine and methionine. Postmortem concentrations of carnitine in liver, muscle, heart, kidney, and brain averaged only one-fourth to one-third those in corresponding tissues of eight normally nourished non-hepatic patients who died after an acute illness of a 1-3-day duration. In the recent years, it has been reported that sirtuin 3 (SIRT3) is protective against acute kidney injury (AKI) and suggest that enhancing SIRT3 to improve mitochondrial dynamics has potential as a strategy for improving outcomes of renal injury. In the current study, it is the first clinical interventional research whether L-carnitine corrects ammonia metabolism associated with liver injury in hepatectomized patients.

対象疾患

介入

依頼者（Sponsor）

実施施設 (1)