単球由来細胞を個々の薬剤効果および肝毒性の代替マーカーとして用いる

基本情報

NCT ID

NCT02353455

ステータス

不明

試験のフェーズ

-

試験タイプ

観察

目標被験者数

300

治験依頼者名

Ludwig-Maximilians - University of Munich

概要

Drug metabolism in the liver is subject to large fluctuations (differences between women and men, people of different ethnic backgrounds, children and adults). These large differences are responsible for very different drug effects and side-effects (and especially liver damage caused by drugs) between individuals. Recent scientific findings suggest that blood derived cells can be used to model individual effects of drugs on the liver reflect inter-individual differences. Since liver damage caused by drugs is a diagnosis of exclusion, the aforementioned cells can be used to identify patients that show higher sensitivity to hepatotoxic side-effects and - in case several drugs are involved - identify the causal agent or possible interactions.

対象疾患

介入

依頼者（Sponsor）

実施施設 (1)