グルカゴン様ペプチド-1欠乏症は、冠動脈疾患における残存リスクなのか？

基本情報

NCT ID

NCT02280837

ステータス

完了

試験のフェーズ

-

試験タイプ

観察

目標被験者数

190

治験依頼者名

Sapporo Medical University

概要

In this study, the investigators hypothesized that significant proportion of patients with coronary artery disease (CAD) has reduced capacity of glucagon-like peptide-1 (GLP-1) secretion, which is detectable as blunted response of plasma active GLP-1 level to oral glucose loading and that reduced GLP-1 secretory function is associated with increased severity of coronary artery stenosis but not with classic risk factors for CAD. To test this hypothesis, the investigators will analyze correlation between GLP-1 secretory capacity and severity of coronary artery stenosis determined by Gensini Score (GS), an established score system for coronary artery stenoses. Additionally, the investigators will analyze relationship between level of "total" GLP-1 and severity of coronary artery stenosis to determine how it is different from the active GLP-1 - coronary stenosis relationship.

対象疾患

介入

依頼者（Sponsor）

実施施設 (1)