SSRI抵抗性強迫性障害を増悪させる非定型抗精神病薬の有効性と安全性

基本情報

NCT ID

NCT00854919

ステータス

完了

試験のフェーズ

第4相

試験タイプ

介入

目標被験者数

-

治験依頼者名

Osaka City University

概要

Objective: Although atypical antipsychotic drugs (AAPDs) have been found effective in the augmentation of serotonin reuptake inhibitors (SRIs) for treatment-resistant obsessive-compulsive disorder (OCD) in short terms trials, there are few data on the effectiveness and safety of these agents in clinical settings over the long term. Method: Subjects (n=46) who responded to selective SRIs (SSRIs) in an initial 12-week trial were continued on SRI-monotherapy plus cognitive-behavioral therapy (CBT) for one year. Subjects (n=44) who failed to respond to SSRIs were randomly assigned to one of 3 AAPDs such as risperidone and were consecutively treated using SSRI+AAPD combined with CBT for a year.

対象疾患

介入

依頼者（Sponsor）

実施施設 (1)