健康な女性ボランティアを対象としたGnRH拮抗薬セトロレリクスの臨床薬理学的研究

基本情報

NCT ID

NCT00628121

ステータス

完了

試験のフェーズ

該当なし

試験タイプ

介入

目標被験者数

31

治験依頼者名

Nippon Kayaku Co., Ltd.

概要

GnRH analogs are globally used for assisted reproduction in infertile patients. To date, in healthy female volunteers the pharmacokinetic and pharmacodynamic profiles of cetrorelix when administered in a single dose have been investigated in studies conducted using doses of 1, 3 and 5 mg. Studies performed in premenopausal female volunteers confirmed that cetrorelix rapidly suppresses luteinizing hormone (LH) and estradiol and shows dose-dependent prolongation of the duration of LH suppression. However, there have been few reports of studies of the relationship between the cetrorelix dosage and its effect on LH surge. In the present study, we investigated the effect of cetrorelix on LH surge when this drug was administered in single doses of 1, 2 and 3 mg.

対象疾患

介入

依頼者（Sponsor）

実施施設 (1)