オフポンプ冠動脈バイパス手術後の心房細動予防におけるカルベジロールとメトプロロールの比較

基本情報

NCT ID

NCT00198614

ステータス

完了

試験のフェーズ

該当なし

試験タイプ

介入

目標被験者数

650

治験依頼者名

Ministry of Health, Labour and Welfare, Japan

概要

Postoperative new-onset atrial fibrillation (AF) is the most common complication stemming from coronary artery bypass graft surgery, and is associated with increased early and late mortality risk. Standard guidelines recommend β blockers for the prevention of AF; however, no prospective study has compared the relative efficacy of β-blocking agents. We hypothesize that carvedilol, a non-selective adrenergic blocker with both anti-inflammatory and antioxidant properties, is more effective than metoprolol, a conventional β1-selective antagonist, in suppressing new-onset AF following off-pump coronary bypass surgery. We have designed the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT) to test our hypothesis in a multi-center, open-label, and randomized controlled trial.

対象疾患

介入

依頼者（Sponsor）

実施施設 (1)